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Abstract #4262

Altered Functional Connectivity of the Motor Network in Multiple System Atrophy

Feng Feng1, Hui You1, Han Wang2, Fuling Zheng1, Chunling Meng1, Jue Wang3, Yufeng Zang3

1Radiology, Peking Union Medical College Hospital, Beijing, China; 2Neurology, Peking Union Medical College Hospital, Beijing, China; 3State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

MSA is mainly a sporadic neurodegenerative disease. Besides abnormalities of nigrostriatal pathway, the typical pathological findings were also described in primary motor and supplementary motor cortices. We hypothesize that there is associated disturbance of functional connectivity of the motor cortex in MSA patients. To test the hypothesis, resting-state functional MRI was used to measure the coherent spontaneous fluctuations in the blood oxygenation levelCdependent signal. Our results showed regional homogeneity changes in left precentral gyrus, right precuneus, supramarginal gyrus and middle frontal gyrus, indicating functional connectivity disturbance of motor-related circuits and left-sided predominance of primary motor cortex involvement.