Federica
Agosta1, Sebastiano Galantucci1, T Stojkovic2,
A. Tomic2, Igor Petrovic2, Giulia Longoni1,
Vladimir Kostic2, Massimo Filippi1
1Neuroimaging Research Unit, Institute
of Experimental Neurology, Division of Neuroscience, Scientific Institute and
University Hospital San Raffaele, Milan, Italy; 2Department of
Neurology, School of Medicine, University of Belgrade, Belgrade, Yugoslavia
Using
TBSS, we investigated WM changes in 39 Parkinsons disease (PD) patients, 20 progressive
supranuclear palsy (PSP) patients (10 Richardsons syndrome [PSP-RS] and 10
PSP-Parkinsonism [PSP-P]), and 26 controls. PSP-RS showed the most pronounced
pattern of decreased FA, including both infratentorial and supratentorial
regions, vs. controls and other patient groups. A similar pattern of FA
decrease (except for superior cerebellar peduncle) was found in PSP-P vs.
controls and PD (only at a lower significance). Impaired WM integrity was
found in PSP but not in PD. The less prominent WM involvement in PSP-P might
be associated to its favorable clinical status.