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Abstract #4263

The Topographical Distribution of White Matter Damage in Parkinsons Disease and Progressive Supranuclear Palsy

Federica Agosta1, Sebastiano Galantucci1, T Stojkovic2, A. Tomic2, Igor Petrovic2, Giulia Longoni1, Vladimir Kostic2, Massimo Filippi1

1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy; 2Department of Neurology, School of Medicine, University of Belgrade, Belgrade, Yugoslavia

Using TBSS, we investigated WM changes in 39 Parkinsons disease (PD) patients, 20 progressive supranuclear palsy (PSP) patients (10 Richardsons syndrome [PSP-RS] and 10 PSP-Parkinsonism [PSP-P]), and 26 controls. PSP-RS showed the most pronounced pattern of decreased FA, including both infratentorial and supratentorial regions, vs. controls and other patient groups. A similar pattern of FA decrease (except for superior cerebellar peduncle) was found in PSP-P vs. controls and PD (only at a lower significance). Impaired WM integrity was found in PSP but not in PD. The less prominent WM involvement in PSP-P might be associated to its favorable clinical status.