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Abstract #4264

The In-Vivo Topographical Distribution of Brain Tissue Loss Associated with Depression in Parkinsons Disease: A Voxel-Based Morphometry Study

Massimo Filippi1, Federica Agosta1, Igor Petrovic2, Sebastiano Galantucci1, Vladana Spica2, Milica Jecmenica2, Vladimir Kostic2

1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy; 2Department of Neurology, School of Medicine, University of Belgrade, Belgrade, Yugoslavia

VBM was used to investigate whether specific patterns of gray (GM) and white matter (WM) loss are associated with depression in 40 patients with Parkinsons disease (PD). Twenty-four PD were diagnosed as non-depressed (PD-NDep), and 16 as having depression (PD-Dep). Compared with PD-NDep, PD-NDep showed WM loss in the right anterior cingulum and inferior orbitofrontal (OF) region. In PD patients, Hamilton rating scale for depression score correlated significantly with right inferior OF WM. The pattern of brain atrophy in PD-Dep overlaps with the key regions involved in major depressive disorders, suggesting an increased vulnerability of this neural circuit in PD.