Elke Hattingen1, Ruediger Hilker2, Joerg Magerkurth1, Carola Seifried2, Ulrich Pilatus1
1Institute of Neuroradiology, University Hospital, Goethe University, Frankfurt, Germany; 2Department of Neurology, University Hospital, Goethe University, Frankfurt, Germany
Combined 31P and 1H spectroscopic imaging was used to study changes in midbrain energy metabolism of patients with Parkinsons disease. Compared to healthy volunteers there is a decrease in high energy phospahtes (ATP an phosphocreatine). The effect is more pronounced in the hemisphere contralateral to the clinacal more affected side. The results corroborate the hypothesis of a potential role of mitochondrial dysfunction in Parkinsons disease.