Elke Hattingen1, Ruediger Hilker2,
Joerg Magerkurth1, Carola Seifried2, Ulrich Pilatus1
1Institute of Neuroradiology,
University Hospital, Goethe University, Frankfurt, Germany; 2Department
of Neurology, University Hospital, Goethe University, Frankfurt, Germany
Combined
31P and 1H spectroscopic imaging was used to study changes in midbrain energy
metabolism of patients with Parkinsons disease. Compared to healthy
volunteers there is a decrease in high energy phospahtes (ATP an
phosphocreatine). The effect is more pronounced in the hemisphere
contralateral to the clinacal more affected side. The results corroborate the
hypothesis of a potential role of mitochondrial dysfunction in Parkinsons
disease.