Abstract #4265

1H and 31P Spectroscopy: High Energy Metabolism in Idiopathic Parkinson Syndrome

Elke Hattingen¹, Ruediger Hilker², Joerg Magerkurth¹, Carola Seifried², Ulrich Pilatus¹

¹Institute of Neuroradiology, University Hospital, Goethe University, Frankfurt, Germany; ²Department of Neurology, University Hospital, Goethe University, Frankfurt, Germany

Combined 31P and 1H spectroscopic imaging was used to study changes in midbrain energy metabolism of patients with Parkinsons disease. Compared to healthy volunteers there is a decrease in high energy phospahtes (ATP an phosphocreatine). The effect is more pronounced in the hemisphere contralateral to the clinacal more affected side. The results corroborate the hypothesis of a potential role of mitochondrial dysfunction in Parkinsons disease.