Santosh Kumar Yadav1, R Murali2,
Vivek A. Saraswat2, R KS Rathore3, A Yadav1,
K N. Prasad4, M A. Thomas5, Rakesh Kumar Gupta1
1Radiodiagnosis, Sanjay Gandhi Post
Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Gastroenterology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India; 3Mathematics and Statistics, Indian Institute of
technology Kanpur, Kanpur, Uttar Pradesh, India; 4Microbiology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India; 5Radiological Sciences, UCLA School of Medicine,
Los Angeles, CA, Los Angeles, CA, United States
Fourteen
patients with ALF, 17 with ACLF and 8 age/sex matched controls were included
in this study. MRI, 1H-MR spectroscopy and serum proinflammatory cytokines
measurements were done in all the patients and controls. Serum
proinflammatory molecules were significantly increased in both conditions as
compared to controls. A significant positive correlation of CS with IL-6 and
TNF-α was observed in ALF while, CS correlated only to IL-6 in ACLF. A
significant negative correlation was observed between MD values and IL-6 in
both conditions. A significant positive correlation was also observed among
Glx/Cr, IL-6 and TNF-α in both conditions. These observations suggest
that proinflammatory cytokines may contribute in the development of CE in
these patients.
Keywords