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Abstract #4267

Absolute Quantification of Human Brain Metabolites in Gulf War Syndrome Using Proton MR Spectroscopy at 3T

Hyeon-Man Baek1, Sergey Cheshkov1,2, Audrey Chang1, Sandeep Ganji1, Evelyn Babcock1, Richard Briggs1,2, Robert Haley2

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States; 2Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

In the present study, metabolic concentrations of three distinct Gulf War (GW) syndromes (e.g., Syndrome-I is described as impaired cognition; syndrome-II, confusion-ataxia; syndrome-III, central pain) were calculated and compared the findings with those for healthy GW veterans. The main observation in this work was the significant reduction of NAA (Syndrome-I, -8%; Syndrome-II, -11%; Syndrome-III, -4%) concentration in left BG and (Syndrome-I, -7%; Syndrome-II, -8%; Syndrome-III, -9%) in right BG of GW syndrome subjects compared to healthy control subjects. The present study demonstrated that quantitative in vivo 1H-MRS can be used to detect the brain abnormalities in GW illness veterans, which may have relevance for the mechanisms of Gulf War syndrome.