Hyeon-Man Baek1, Sergey Cheshkov1,2,
Audrey Chang1, Sandeep Ganji1, Evelyn Babcock1,
Richard Briggs1,2, Robert Haley2
1Radiology, UT Southwestern Medical
Center, Dallas, TX, United States; 2Internal Medicine, UT
Southwestern Medical Center, Dallas, TX, United States
In
the present study, metabolic concentrations of three distinct Gulf War (GW)
syndromes (e.g., Syndrome-I is described as impaired cognition;
syndrome-II, confusion-ataxia; syndrome-III, central pain) were calculated
and compared the findings with those for healthy GW veterans. The main
observation in this work was the significant reduction of NAA (Syndrome-I,
-8%; Syndrome-II, -11%; Syndrome-III, -4%) concentration in left BG and
(Syndrome-I, -7%; Syndrome-II, -8%; Syndrome-III, -9%) in right BG of GW
syndrome subjects compared to healthy control subjects. The present study
demonstrated that quantitative in vivo 1H-MRS can be used to detect the brain
abnormalities in GW illness veterans, which may have relevance for the
mechanisms of Gulf War syndrome.