Correlation Between Diffusion Tensor and Perfusion Imaging in Segmented Enhancing Lesion with High Grade Glioma

Naomi Morita^1,2, Masafumi Harada¹, Eva Zacharaki², Priyanka Bhatt², Sanjeev Chawla², Elias R. Melhem², Hiromu Nishitani¹

Knowledge about microvascularity, angiogenesis or tumor cellularity is important in determing tumor grade. The purpose of this study was to determine whether there are any correlations between ADC, FA and rTBV value in segmented enhancing lesion within tumor. Thirty three brain tumor patients with contrast enhancement on MRI underwent DTI and PWI. FA, ADC and rTBV values were measured in the segmented enhancing area within tumor. FA and rTBV had a negative correlation (p<0.05). This study indicates that damage of fiber and tumor progression may have any relationships in the course of tumor progression.