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Abstract #4299

Quantitative MRI Analysis of Lacrimal Glands in Patients with Sickle Cell Disease

Elliott Elias1, Joseph Liao1, Memi Watanabe1, Naoko Saito1, Hernan Jara1, Osamu Sakai1

1Boston Medical Center, Boston University School of Medicine, Boston, MA, United States

Purpose: To analyze MR relaxometric and volumetric changes in lacrimal glands in sickle cell disease (SCD) as motivated by a recent case report on lacrimal gland pathology. Materials and Methods: 15 SCD patients (19.8-43.6 yrs) and 23 control subjects (23-64 yrs) were imaged by mixed-TSE sequence at 1.5T. T1, T2, and secular-T2 relaxation time histograms and volumes were analyzed. Results: T2 and secular-T2 relaxation times were significantly shortened in SCD patients, and glandular volumes were increased. No significant differences were observed in T1. Conclusion: Disease specific relaxometric and volumetric were observed in the lacrimal glands of SCD patients.