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Abstract #4300

Quantitative MRI Analysis of Craniofacial Bone Marrow in Patients with Sickle Cell Disease

Elliott Elias1, Joseph Liao1, Memi Watanabe1, Yu Sakai1, Kaan Erbay1, Naoko Saito1, Hernan Jara1, Osamu Sakai1

1Boston Medical Center, Boston University School of Medicine, Boston, MA, United States

Purpose: To analyze MR relaxometric and volumetric changes in craniofacial bone marrow in sickle-cell disease (SCD). Materials and Methods: 15 SCD patients (19.8-43.6 yrs) and 23 controls (23-64 yrs) were imaged by mixed-TSE sequence at 1.5T. Craniofacial bones were manually segmented, and T1, T2, and secular-T2 relaxation time histograms and volumes were analyzed. Results: T2 and secular-T2 peaks revealed significant shortening in SCD patients. Only the first T1 peak showed significant increase. Significant increase in marrow volume was observed in SCD patients. Conclusion: Disease specific relaxometric and volumetric changes were observed in the craniofacial bone marrow in SCD patients.