Meeting Banner
Abstract #4315

Diffusional Kurtosis Imaging of Gray Matter in Patients with Multiple Sclerosis

Maxim Bester1,2, Jens H. Jensen1, Ali Tabesh1, Hina Jaggi1, Cathy Hu1, Joseph Herbert3, Robert I. Grossman1, Matilde Inglese, 3,4

1Radiology, New York University, New York, NY, United States; 2Neuroradiology, Eppendorf-Hamburg University, Hamburg, Germany; 3Neurology, New York University, New York, NY, United States; 4Radiology , New York University, New York, NY, United States

Diffusion tensor imaging (DTI) is useful to assess subtle pathology in normal-appearing white matter of multiple sclerosis (MS) patients. Diffusional kurtosis imaging (DKI) measures the non-Gaussian water diffusion and mean kurtosis (MK) is sensitive to structural changes in isotropic tissue such as gray matter (GM). The aims of this study were to assess GM in MS patients using DKI and DTI and to investigate the relationship between GM MK and white matter injury. Differences from controls were observed in both GM MK and DTI metrics suggesting that DKI can provide additional complementary information about brain tissue microstructure