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Abstract #4316

Magnetization Transfer DTI in Multiple Sclerosis

Alexandru Vlad Avram1, Arnaud Guidon1, Jeffrey Petrella, Joel Morgenlander2, Allen W. Song

1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States; 2Department of Neurology, Duke University

We present a stimulated echo DTI sequence with magnetization transfer capable of imaging the diffusion anisotropy of myelin water and evaluate its potential for early detection of white matter abnormalities in multiple sclerosis. The observed myelin-specific FA changes clearly indicated the underlying demyelination in MS patients, and the degrees of the FA changes may further characterize the stage of disease progression, which may lead to an early detection of areas undergoing initial myelin microstructural changes before any significant myelin content reduction.