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Abstract #4321

Evidence of Distributed Subpial T2* Signal Changes at 7T in Multiple Sclerosis: An Histogram Based Approach.

Caterina Mainero1, Carlos Lima1, Julien Cohen-Adad1, Doug Greve1, Amy Radding1, Thomas Benner1, R Philip Kinkel2, Bruce Fischl1, Bruce R. Rosen1

1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States

We investigated whether a histogram-based analysis of 7T T2* signal intensity in the cortex can show distributed subpial cortical changes in 14 patients with multiple sclerosis (MS), as described histopathologically. We hypothesized that this show significantly increased T2* signal intensity in patients vs controls. FLASH-T2* spoiled gradient-echo weighted images acquired at 7T. Pial and white matter surfaces generated by FreeSurfer on a 3T MEMPR were overlaid on the 7T FLASH-T2* images. T2* intensities were normalized to mean CSF intensity (T2*/CSF ) and then sampled 1mm inside the pial surface. The histogram-based analysis showed significant, diffuse T2*/CSF signal increases in MS vs matched controls, particularly evident in frontal areas.