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Abstract #4322

Optimisation of 3 T and 7 T T2*-Weighted MRI for the Detection of Small Parenchymal Veins in MS Lesions

Jennifer Elizabeth Dixon1, Matthew John Brookes1, Emma C. Tallantyre2, Nikos Evangelou2, Peter G. Morris1

1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Department of Clinical Neurology, Nottingham University Hospital NHS Trust, Nottingham, Nottinghamshire, United Kingdom

Post-mortem studies of MS lesions show a close spatial relationship to parenchymal veins. In vivo study of this has previously been limited by the difficulties in demonstrating both lesions and veins on a single MR image. Recently, we have shown that T2*-weighted MRI at 7T enables simultaneous visualisation of both structures, and found that 82% of white-matter MS lesions contained a detectable vein. Here, we predict optimal scanning parameters for increasing the sensitivity of vessel detection and reducing the inherent bias towards detection of veins with particular orientations.