Robert Marc Lebel1, Amir Eissa1,
Peter Seres1, Derek J. Emery2, Gregg Blevins3,
Alan H. Wilman1
1Biomedical Engineering, University of
Alberta, Edmonton, Alberta, Canada; 2Radiology and Diagnostic
Imaging, University of Alberta, Edmonton, Alberta, Canada; 3Neurology,
University of Alberta, Edmonton, Alberta, Canada
Three
iron-sensitive methods are applied at 4.7T for tracking iron-based changes in
the brain of patients with relapsing-remitting multiple sclerosis (MS). The methods are phase susceptibility, R2
and R2* mapping. Each method is
applied with special high field adaptations. They are used to track lesion
progression as well as deep grey matter changes. Each measure provides unique contrast and
its own sensitivity and specificity to iron.
Together these methods can provide new insight into MS progression.
Keywords