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Abstract #4332

Serial Whole-Brain N-Acetylaspartate Concentration in Multiple Sclerosis Patients

Daniel Rigotti1, Matilde Inglese1, Nissa Perry1, James Babb1, Joseph Herbert2, Oded Gonen1

1Radiology, NYU School of Medicine, New York, NY, United States; 2Neurology, NYU School of Medicine, New York, NY, United States

The irreversible effects of multiple sclerosis are chiefly caused by neuronal loss. The global concentration of the neuron-specific amino-acid derivative N-acetylaspartate (WBNAA1) has been shown to be a sensitive marker for diffuse neurodegeneration in cross-sectional studies. Here we show data from a year-long longitudinal study of nineteen newly-diagnosed MS patients where we detect a significant and biologically relevant serial decline in WBNAA. This is the first time, to our knowledge, that quantifiable changes reflecting ongoing pathogenesis have been measured in MS using WBNAA.