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Abstract #4333

Classification of Multiple Sclerosis Clinical Forms by 1H Magnetic Ressonance Spectroscopy of Cerebrospinal Fluid

Francesc Xavier Aymerich1,2, Julio Alonso1, Manuel Comabella3, Miquel E. Cabaas4, Mar Tintor3, Xavier Montalban3, Alex Rovira1

1Unitat RM Vall Hebron (IDI), Hospital Vall Hebron, Barcelona, Spain; 2Enginyeria de Sistemes, Automtica i Informtica Industrial, Universitat Politcnica de Catalunya, Barcelona, Spain; 3Unitat Neuroimmunologia Clnica, CEM Cat, Hospital Vall Hebron, Barcelona, Spain; 4Servei Ressonncia Magntica Nuclear, Universitat Autnoma de Barcelona, Cerdanyola del Valls, Barcelona, Spain

The purpose was the design of a fuzzy classifier to differentiate among primary progressive multiple sclerosis (MS), relapsing remitting MS and non-MS conditions by 1H-NMR spectroscopy of cerebrospinal fluid. The design considered the fusion of classifiers based on fuzzy decision trees. We considered three different datasets (aliphatic region, aromatic region and the aggregation of both regions). We evaluated for each dataset the classifier performance by means of two classification quality indexes (correctness and robustness). Results showed mean classification correctness and robustness in the intervals [0.92,1] and [0.34,0.50] respectively. The aggregation of aliphatic and aromatic regions provided the best results.