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Abstract #4349

Effect of Central Nervous System Involvement in Systemic Lupus Erythematosus Patients : Examination Using Diffusion Parameters and Volumetric Measurement

Shiou-Ping Lee1, Jie-Zhi Cheng2, Wen-Yang Chiang3, Chung-Ming Chen2, Kao-Lun Wang1

1Department of Medical Imaging and Technology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipei, Taiwan

None of systemic lupus erythematosus (SLE) studies examined diffusion tensor imaging (DTI) and volumetric measurement in the same groups. This paper aimed to investigate the effect of central nervous system (CNS) involvement in SLE patients on two diffusion parameters, i.e., fractional anisotropy (FA) and mean diffusivity (MD), and one volumetric measurement, i.e., volume. To accurately define the corpus callosum boundaries, an automatic segmentation algorithm, cell-competition method, was adopted to delineate the boundaries of the corpus callosum on mid-sagittal FA maps to calculate FA, MD and volume of corpus callosum.