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Abstract #4350

In Vivo Vascular Hallmarks of Diffuse Leukoaraiosis

Jinsoo Uh1, Uma Yezhuvath1, Yamei Cheng1, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

We characterized multiple domains of vascular changes in leukoaraiosis using in vivo MR techniques. Compared to NAWM, CBF in leukoaraiosis regions was 38% lower (p=0.01) and CVR was 48% lower (p=0.005). Significant BBB leakage was also detected (p=0.04). Quantitative analysis revealed that the extent of BBB leakage was positively correlated with apparent diffusion coefficient. In addition, the total area of leukoaraiosis in the brain is correlated with the CVR in NAWM. This study shows that the vascular changes in leukoaraiosis include both an ischemic and a toxicity component, suggesting a central role of vascular endothelium in the formation of leukoaraiosis.