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Abstract #4359

Large-Scale ADC Histogram Analysis of the Brain Aging: Normal Versus Abnormal (667 Subjects, 2 Days-93.8 Years)

Memi Watanabe1, Noreen Ward1, Al Ozonoff2, Steven Kussman1, Koji Tanabe1, Kaan Erbay1, Naoko Saito1, Hernan Jara1,3, Osamu Sakai1

1Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States; 2Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States; 3Department of Biomedical Engineering, Boston University, Boston, MA, United States

Purpose: To study age dependencies of ADC histogram and impact of brain abnormalities on ADC in a large and wide age ranged population. Methods: Brain data of 667 subjects (2 days-93.8 years) were obtained by DW-SE-sshEPI and ADC histograms of the whole brain were generated. The subjects were divided into normal and abnormal groups by MR findings and clinical histories. Results: The abnormal group showed higher ADC peak values compared with the normal. Conclusion: The aging patterns of ADC peak values of normal and abnormal brain groups have been demonstrated in a large and wide age ranged population.