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Abstract #4367

Clinical 1H MRS Studies of Glutamatergic Neurotransmission in Bipolar Disorder

Wen-Jang Chu1,2, Mathew Norris3, Renu Kotwal, Caleb M. Adler, Mi-Jung Kim, Rachel Whitsel, Jing-Huei Lee, 23, Melissa P. DelBello, Stephen M. Strakowski, 2

1Psychiatry, Univ. of Cincinnati, Cincinnati, OH, United States; 2Center for Imaging Research, Univ. of Cincinnati, Cincinnati, OH, United States; 3Biomedical Engineering, Univ. of Cincinnati

Glutamate (Glu) has been found play an important role in Bipolar Disorder (BD). The accurate measurement of Glu has been hurdled by the large signals overlapping and broadening baseline. Instead of reporting Glu levels, the Glx (sum of glutamate, glutamine and GABA) has been widely used in glutamatergic neurotransmission research. In this work, we studied Glu levels using short echo PRESS spectroscopy, and TE-averaged spectroscopy in medication-free, lithium-treated BD patients and healthy volunteers. The results have allowed us to evaluate the Glu level differences between the two groups, and the effect of lithium treatment on Glu levels.