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Abstract #4368

Impaired Brain Circuitry and High-Energy Phosphates in Bipolar Disorder

Wen-Jang Chu1,2, Amanda Stover3, Jonathan Dudley4, David Caldwell2, Amanda Marie Opaskar2, Mathew Norris4, Martine Lamy2,3, Jane Allendorfer2,3, Stephen M. Strakowski1,2, Jing-Huei Lee2,4, James C. Eliassen1,2

1Psychiatry, Univ. of Cincinnati, Cincinnati, OH, United States; 2Center for Imaging Research, Univ. of Cincinnati, Cincinnati, OH, United States; 3Graduate Program in Neuroscience, Univ. of Cincinnati; 4Biomedical Engineering, Univ. of Cincinnati

The combined approach of fMRI and 31P spectroscopy is used to investigate 1) abnormal brain activation, and 2) the correlation between high-energy phosphates and abnormal activation in the brains of patients with bipolar disorder. A behavioral task, the Balloon Analogue Risk Task, was used during fMRI to identify brain regions that differed between bipolar and healthy subjects. Several regions within anterior limbic network such as amygdala, ventrolateral prefrontal cortex and orbitofrontal cortex were identified by fMRI activation differences. 31P MRSI data showed significant alterations of Pi, PDE and PCr in some of these regions.