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Abstract #4370

Increased Anterior Cingulate GABA Level Following Electroconvulsive Therapy in Patients with Major Depressive Episodes

Pallab Bhattacharyya1, Erik Beall1, Mark Lowe1, Micheal Phillips1, David Muzina1

1Cleveland Clinic, Cleveland, OH, United States

Gamma amino butyric acid (GABA) level in anterior cingulate is known to be reduced in depression patients. Electroconvulsive therapy (ECT) is a commonly used treatment for major depressive episodes (MDE). Using 1H spectroscopy we have measured anterior cingulate GABA level 2 weeks before and 1-2 weeks after ECT treatment in MDE patients. Our preliminary data show an increase in anterior cingulate GABA level following ECT in MDE patients.