Arabhi C. Nagasunder1, Lisa Paquette2,
Caroline Jane Tavare3, Tena Rosser4, Floyd H. Gilles3,
Marvin D. Nelson1, Stefan Bluml1,5, Ashok Panigrahy1,6
1Department of Radiology, Childrens
Hospital Los Angeles, Los Angeles, CA, United States; 2Division of
Neonatology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 3Department
of Neuropathology, Childrens Hospital Los Angeles, Los Angeles, CA, United
States; 4Division of Neurology, Childrens Hospital Los Angeles,
Los Angeles, CA, United States; 5Rudi Schulte Research Institute,
Santa Barbara, CA, United States; 6Department of Radiology,
Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States
Neonatal
brain is highly vulnerable to injury resulting in subsequent cognitive and
motor disabilities. Our goal was to show that there are microstructural
abnormalities in regions of the brain separate from the focal necroses in
non-cystic periventricular leukomalacia. A diverse cohort of neonates was
scanned at term equivalent age using DTI. We found that there is
microstructural injury in white matter regions both proximal and distant from
necrotic foci.