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Abstract #4398

A Combined Brain Proton MR Spectroscopy and Amplitude- Integrated Electroencephalography Study in Term Newborns with Hypoxic-Ischemic Encephalopathy

Caterina Tonon1, Claudia Testa1, David Neil Manners1, Emil Malucelli1, Gina Ancora2, Giovanni Tani3, Paolo Ambrosetto3, Bruno Barbiroli1, Raffaele Lodi1

1MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy, Italy; 2Institute of Neonatology, Department of Woman, Child and Adolescent Health,, Policlinico SOrsola-Malpighi, Bologna, Italy; 3Paediatric Radiology Unit, Department of Woman, Child and Adolescent Health, Policlinico SOrsola-Malpighi, Bologna, Italy

Perinatal hypoxic ischemic encephalopathy (HIE) remains a frequent cause of neurological sequelae and death. The accurate assessment of HIE is crucial for determining the prognosis.The aim of the study was to relate the brain metabolic changes detected by 1H-MRS to the amplitude integrated- electroencephalogram (a-EEG) time course findings in newborns at term and to evaluate their correlation with outcome. Both 1H-MRS and a-EEG findings showed a good correlation with the severity and the outcome of cerebral HI injury. These data, obtained from 1H-MRS and a-EEG in non-treated infants, represent reference data for future investigations to select candidates for cool cap therapy.