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Abstract #4397

Effects of the Cumulative Exposure to Lypopolysaccharide and Hyperoxia on the Developing Rat Brain Assessed by High-Field Diffusion Tensor Imaging

Yohan van de Looij1,2, Marco Sifringer3, Felix Brehmer4, Bettina Gerstner5, Petra S. Hppi1, Rolf Gruetter2,6, Ursula Felderhoff-Mser7, Stphane V. Sizonenko1

1Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland; 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Department of Anesthesiology, Charit-Universittsmedizin Berlin, Berlin, Germany; 4Department of Neonatology, Charit-Universittsmedizin Berlin, Berlin, Germany; 5Department of Pediatric Cardiology, University Hospital Giessen, Giessen, Germany; 6Department of Radiology, University of Geneva and Lausanne, Geneva and Lausanne, Switzerland; 7Department of Pediatrics, University Hospital Essen, Essen, Germany

In premature infants, periventricular leukomalacia (PVL) is a common type of cerebral white matter injury and animal models of PVL can be achieved by lipopolysaccharide (LPS) exposure. Furthermore, premature infants are subjected much earlier to relative hyperoxia, because of a dramatic rise of oxygen tissue tension compared with intrauterine conditions but hyperoxia is supposed to negatively influence brain development and maturation. The goal of this study was to characterize changes in the pup rat brain following LPS and/or hyperoxia exposure by DTI derived parameters. This study confirmed white matter damages following LPS injection and/or Hyperoxia revealed by DTI derived parameters.