Yohan van de Looij1,2, Marco Sifringer3,
Felix Brehmer4, Bettina Gerstner5, Petra S. Hppi1,
Rolf Gruetter2,6, Ursula Felderhoff-Mser7, Stphane V.
Sizonenko1
1Division of Child Growth &
Development, Department of Pediatrics, University of Geneva, Geneva,
Switzerland; 2Laboratory for Functional and Metabolic Imaging,
Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Department
of Anesthesiology, Charit-Universittsmedizin Berlin, Berlin, Germany; 4Department
of Neonatology, Charit-Universittsmedizin Berlin, Berlin, Germany; 5Department
of Pediatric Cardiology, University Hospital Giessen, Giessen, Germany; 6Department
of Radiology, University of Geneva and Lausanne, Geneva and Lausanne,
Switzerland; 7Department of Pediatrics, University Hospital Essen,
Essen, Germany
In
premature infants, periventricular leukomalacia (PVL) is a common type of
cerebral white matter injury and animal models of PVL can be achieved by
lipopolysaccharide (LPS) exposure. Furthermore, premature infants are
subjected much earlier to relative hyperoxia, because of a dramatic rise of oxygen
tissue tension compared with intrauterine conditions but hyperoxia is
supposed to negatively influence brain development and maturation. The goal
of this study was to characterize changes in the pup rat brain following LPS
and/or hyperoxia exposure by DTI derived parameters. This study confirmed
white matter damages following LPS injection and/or Hyperoxia revealed by DTI
derived parameters.
Keywords