Aziz M. Ulug1, An Vo1, Elisabeth
Kozora2,3, Glendalee Ramon4, Joann Vega4,
Robert D. Zimmerman5, Doruk Erkan4, Michael D. Lockshin4
1The Feinstein Institute for Medical
Research, Manhasset, NY, United States; 2National Jewish Heath,
Denver, CO, United States; 3University of Colorado Medical Center,
Denver, CO, United States; 4Hospital for Special Surgery, New
York, United States; 5Weill Medical College of Cornell University,
New York, United States
Fourteen
SLE patients, five APL patients and four normal controls were studied using
fMRI and DTI. We found significant DTI
and fMRI differences among three groups.
In both patient groups, word generation task shows abnormal activation
patterns in the frontal areas suggestive of recruitment of these areas during
these tasks. In the hippocampal area,
there is a significant difference between APL and SLE group during N-back,
word generation and rhyming tasks. In addition to regional differences, there
is also whole brain diffusion changes between the patient groups and
controls.
Keywords