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Abstract #4467

Retinotopy Extension in Primary Visual Cortex Associated with Perimetry Improvement in a Case of Hemianopia After Visual Restoration Therapy

Yi-Ching Lynn Ho1,2, Amandine Cheze2, Esben Thade Petersen2,3, Albert Gjedde1,4, Kong-Yong Goh5, Yih-Yian Sitoh2, Xavier Golay2,6

1CFIN, University of Aarhus, Aarhus, Denmark; 2Neuroradiology, National Neuroscience Institute, Singapore, Singapore; 3Clinical Imaging Research Centre, NUS, Singapore; 4University of Copenhagen, Denmark; 5Eye Institute, Tan Tock Seng Hospital, Singapore; 6Institute of Neurology, UCL, London, United Kingdom

So far, no clear physiological correlates have been given for the apparent visual field improvements of patients with post-chiasmal lesions after treatment, such as Visual Restoration Therapy (VRT). Using fMRI retinotopic mapping, we assessed a patient with complete homonymous hemianopia before and after VRT. The patient demonstrated residual neurovascular function and limited retinotopic organization around the lesion before therapy. Post therapy, the retinotopic representation around the lesion was modestly extended along with perimetry improvements, which may, to our knowledge, be the first report on primary visual cortex retinotopy recovery via ad hoc treatment of a patient with visual field loss.