Richa Trivedi1, Shruti Agarwal2,
Vipul Shah3, Puneet Goyal4, Vimal K. Paliwal5,
Ram KS Rathore6, Rakesh Kumar Gupta7
1NMR Research Centre, Institute of
Nuclear Medicine and Allied Sciences, Delhi, India; 2Mathematics
and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India;
33Pediatric Orthopedic Surgery unit, Bhargava Nursing Home,
Lucknow, Uttar Pradesh, India; 4Anesthesiology, Sanjay Gandhi Post
Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 5Neurology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India; 6Mathematics and Statistics, Indian Institute of
Technology, , Kanpur, Uttar Pradesh, India; 7Radiodiagnosis,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India
Diffusion
tensor tractography using FACT algorithm was performed on 39 children with
different grades of cerebral palsy (CP) defined using the Gross Motor
Function Classification System (GMFCS) to look for probable correlation
between tract-specific DTI metrics in sensorymotor pathways and clinical
grades. A significant inverse correlation was observed between fractional
anisotropy (FA) in both sensory and motor pathways and clinical grades. In
this study we extend our understanding of the pathophysiology of CP by
showing that DTI measures in both motor and sensory pathways reflects the
degree of motor deficits.