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Abstract #4481

Lateralisation of Perisylvian Pathways with Age in Aspergers Syndrome a Cross-Sectional DTI Study

Sanja Budisavljevic1, Flavio Dell'Acqua, Stephanie Forkel, Michel Thiebaut de Schotten, Marco Catani

1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College, London, United Kingdom

Using DT-MRI tractography we investigated lateralisation of perisylvian pathways with age in Aspergers Syndrome. We observed that the indirect pathway of the arcuate fasciculus shows abnormal development with age in people with Aspergers syndrome compared to controls. This suggests that abnormalities in white matter development may be a key feature of autism spectrum disorders and may explain impairments in language and communication.