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Abstract #4483

Deformable Registration and Tract-Based Spatial Analysis of Diffusion Tensor MR Images in Mild Traumatic Brain Injury of Military-Related Blast Injury

Ping-Hong Yeh1, Binquan Wang, Terrence R. Oakes, 2, Louis M. French3, David F. Moore3, Gerard Riedy, 2,4

1Henry Jackson Foundation for Military Medicine, Rockville, MD, United States; 2National Capital Neuroimaging Consortium, Walter Reed Army Medical Center, Washington DC; 3Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center,; 4Department of Radiology and Radiological Sciences, Uniformed Services University

Evaluating the white matter disruption in mild traumatic brain injury (mTBI) is challenging. The study investigated mTBI in military-related blast injury using diffusion tensor imaging. High-dimensional spatial normalization of diffusion tensor images, atlas reconstruction and tract-based spatial analysis were applied to assess the physiological and geometric changes in mTBI, and their relationships with neuropsychopathic symptoms. The features of micro- and macro-structural changes varied within the mTBI group. Greater severity of neuropsychopathic symptoms was associated with the disconnection in fronto-(sub)cortical, fronto-limbic and inter-hemispheric circuitry. Optimizing spatial normalization method can help detect white matter disruption in mTBI using a low field clinical scanner.