Elan J. Grossman1, Yulin Ge1,
Jens H. Jensen1, James S. Babb1, Joseph Reaume1,
Jonathan A. Silver2, Robert I. Grossman1, Matilde
Inglese1
1Center for Biomedical Imaging,
Department of Radiology, NYU School of Medicine, New York, United States; 2Department
of Psychiatry, NYU School of Medicine, New York, United States
While
conventional imaging has been unsuccessful detecting cerebral damage in mild
traumatic brain injury (MTBI), investigations using DTI report evidence of
diffuse axonal injury. The purpose of the current study is to assess whether
DKI, which measures non-Gaussian diffusion of water, can provide additional
complimentary information about MTBI pathology. In addition to white matter
regions we investigated thalamus and basal ganglia in patients with MTBI
using DKI and DTI. Differences from controls were observed in thalamus and
posterior internal capsule of acute and chronic MTBI patients. This suggests
that DKI and DTI might be prognostic markers of persistent post-concussive
syndrome.