Jeff F. Dunn1,2, Thorarin A. Bjarnason3, Tonima Ali3, Ying Wu1,2, Cheryl R. McCreary1,2, Ross J. Mitchell, 2,4
1Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; 2Department of Radiology, University of Calgary, Calgary, Alberta, Canada; 3Biomedical Engineering, University of Calgary; 4Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Quantitative T2 (qT2) has been used to identify a range of pathophysiology in brain including multiple sclerosis. We have extended the application of qT2 to that of assessing heterogeneity of stroke within an experimental infarct in a rat brain. We have applied a recently published voxel-based approach, which allows for assessment of heterogeneity of T2 components. It was determined that the proportion of the total T2 which relates to the 50-60ms range results in visualization of the periphery of the infarct. This type of approach may be useful in identification of the ischemic penumbra.