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Abstract #4491

T2 Component area Fractions: A Possible Marker for Ischemic Penumbra

Jeff F. Dunn1,2, Thorarin A. Bjarnason3, Tonima Ali3, Ying Wu1,2, Cheryl R. McCreary1,2, Ross J. Mitchell, 2,4

1Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; 2Department of Radiology, University of Calgary, Calgary, Alberta, Canada; 3Biomedical Engineering, University of Calgary; 4Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

Quantitative T2 (qT2) has been used to identify a range of pathophysiology in brain including multiple sclerosis. We have extended the application of qT2 to that of assessing heterogeneity of stroke within an experimental infarct in a rat brain. We have applied a recently published voxel-based approach, which allows for assessment of heterogeneity of T2 components. It was determined that the proportion of the total T2 which relates to the 50-60ms range results in visualization of the periphery of the infarct. This type of approach may be useful in identification of the ischemic penumbra.