Silun Wang1,2, ED X. WU3, Ho-fai
Lau3, Jing Gu1, Jinyuan Zhou2, Pek-lan Khong1
1Diagnostic Radiology, The University
of Hong Kong, Hong Kong, Hong Kong; 2Radiology, Johns Hopkins
University School of Medicine, Baltimore, MD, United States; 3Laboratory
of Biomedical Imaging and Signal Processing, The University of Hong Kong,
Hong Kong, Hong Kong
We
evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI
neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased
FA in multiple injured WM tracts, including external capsule (EC), fornix
(F), cerebral peduncle (CP) and optical tracts (OT), at different time
points, but no differences were demonstrated in anterior commissure
(AC). Our results support the use of
DTI as an imaging biomarker to non-invasively monitor the severity and
longitudinal changes of mild HI-induced WM injury. Different severity and
patterns of WM tract injury may reflect disturbances of cerebral blood supply
in this ischemic animal model.