Asamoah Bosomtwi1,2, Quan Jiang2,3,
Li Zhang2, Zheng Gang Zhang2,3, Michael Chopp2,3
1Yerkes Imaging Center, Emory
University, Atlanta, GA, United States; 2Neurology, Henry Ford
Hospital, Detroit, MI, United States; 3Physics, Oakland
University, Rochester, MI, United States
We
investigated vascular remodeling after stroke using MRI mean segment length
(MSL) and vessel size index (VSI) measurement and correlate the results with
measurements using Laser Scanning Confocal Microscopy (LSCM). We demonstrate
that MRI MSL and VSI can detect the microvascular status of brain tissue with
different ischemic damage. The MSL and VSI measured by MRI were highly
correlated with LSCM histological measurements. Our data demonstrate that
these MRI measurements can quantitatively evaluate microvascular remodeling
after stroke.
Keywords