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Abstract #4494

Comparison of MRI Measured Mean Micro-Vessel Segment Length and Micro-Vessel Radius and Laser Scan Confocal Microscopy After Embolic Stroke

Asamoah Bosomtwi1,2, Quan Jiang2,3, Li Zhang2, Zheng Gang Zhang2,3, Michael Chopp2,3

1Yerkes Imaging Center, Emory University, Atlanta, GA, United States; 2Neurology, Henry Ford Hospital, Detroit, MI, United States; 3Physics, Oakland University, Rochester, MI, United States

We investigated vascular remodeling after stroke using MRI mean segment length (MSL) and vessel size index (VSI) measurement and correlate the results with measurements using Laser Scanning Confocal Microscopy (LSCM). We demonstrate that MRI MSL and VSI can detect the microvascular status of brain tissue with different ischemic damage. The MSL and VSI measured by MRI were highly correlated with LSCM histological measurements. Our data demonstrate that these MRI measurements can quantitatively evaluate microvascular remodeling after stroke.