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Abstract #4495

Cell-Based Treatment Induced White Matter Reorganization After Traumatic Brain Injury Measured by Gaussian, Q-Space DTI, and Histology

Quan Jiang1,2, Guang Liang Ding, Siamak Pourabdollah-Nejad1, Chang Sheng Qu3, Asim Mahmood3, Li Zhang1, Zheng Gang Zhang1, Jiani Hu4, Nassan Bagher-Ebadian1, James R. Ewing1, Michael Chopp1,2

1Neurology, Henry Ford Health System, Detroit, MI, United States; 2Physics, Oakland University, Rochester, MI, United States; 3Neurosurgery, Henry Ford Health System, Detroit, MI, United States; 4MR Center, Wayne State University, Detroit, MI, United States

We investigated cell-based treatment induced white matter remodeling after traumatic brain injury (TBI) using Gaussian, q-ball, standard deviation (SD) DTI, and immuno-histochemistry staining. We demonstrate that in brain tissue with a preponderance of single oriented fibers, Gaussian DTI can correctly identify white matter reorganization and detect changes of axonal orientation in the boundary recovery region after TBI. However, SD and q-ball need to be employed to measure WM reorganization if substantial fiber crossing is present in the recovery tissue. Our data suggest that combination SD and FA data may provide information about the stage of white matter remodeling after TBI.