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Abstract #4496

Effect of Mesenchymal Stem Cells on the Cerebral Microvascularisation in a Rat Model of Stroke: MRI Study

Anaick Moisan1, Emmanuelle Grillon1, Emmanuel L. Barbier1, Florence De Fraipont2, Chantal Remy1, Marie-Jeanne Richard2,3, Olivier Detante1,4

1INSERM U836 / Joseph Fourier University (Functional and Metabolic Imaging), Grenoble Institute of Neurosciences (GIN), Grenoble, France, Metropolitan; 2INSERM U823 / Joseph Fourier University, Albert Bonniot Institute, Grenoble, France, Metropolitan; 3Cell and Tissue Therapy Unit, University Hospital, Grenoble, France, Metropolitan; 4Stroke Unit, Department of Neurology, University Hospital, Grenoble, France, Metropolitan

In a rat model of stroke, the effects of human mesenchymal stem cells (hMSC) on the evolution of microvascularisation were studied. Seven days after transient cerebral ischemia, rats received a 10L intracerebral administration of either cell culture medium or 4105 hMSC. Two groups of healthy control rats underwent the same treatment. Groups were followed by MRI during 21 days (ADC, cerebral blood volume (CBV), vessel size (VSI)). One day after IC administration, hMSC abolish the CBV increase commonly observed after transient cerebral ischemia. VSI estimates suggest that hMSC also delay the vasodilation secondary to cerebral ischemia.