Anaick
Moisan1, Emmanuelle Grillon1, Emmanuel L. Barbier1,
Florence De Fraipont2, Chantal Remy1, Marie-Jeanne Richard2,3,
Olivier Detante1,4
1INSERM U836 / Joseph Fourier University
(Functional and Metabolic Imaging), Grenoble Institute of Neurosciences
(GIN), Grenoble, France, Metropolitan; 2INSERM U823 / Joseph
Fourier University, Albert Bonniot Institute, Grenoble, France, Metropolitan;
3Cell and Tissue Therapy Unit, University Hospital, Grenoble,
France, Metropolitan; 4Stroke Unit, Department of Neurology,
University Hospital, Grenoble, France, Metropolitan
In
a rat model of stroke, the effects of human mesenchymal stem cells (hMSC) on
the evolution of microvascularisation were studied. Seven days after
transient cerebral ischemia, rats received a 10L intracerebral
administration of either cell culture medium or 4105 hMSC. Two groups of
healthy control rats underwent the same treatment. Groups were followed by
MRI during 21 days (ADC, cerebral blood volume (CBV), vessel size (VSI)). One
day after IC administration, hMSC abolish the CBV increase commonly observed
after transient cerebral ischemia. VSI estimates suggest that hMSC also delay
the vasodilation secondary to cerebral ischemia.