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Abstract #4497

Microvascular Density Quantitative Changes After Rat Embolic Stroke Using MRI

Asamoah Bosomtwi1,2, Quan Jiang2,3, Guanlian Ding2, Li Zhang2, Zheng Gang Zhang2,3, Mei Lu4, James R. Ewing2,3, Michael Chopp2,3

1Yerkes Imaging Center, Emory University, Atlanta, GA, United States; 2Neurology, Henry Ford Hospital, Detroit, MI, United States; 3Physics, Oakland University, Rochester, MI, United States; 4Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI, United States

We investigated vascular remodeling after stroke using MRI microvascular density (MVD) measurement and gold standard immuno-histochemistry staining. We demonstrate that MRI MVD detect the microvascular status of brain tissue with different ischemic damage. The MVD measured by MRI was highly correlated with histological measures of MVD. Our data demonstrate that MRI MVD measurement can quantitatively evaluate microvascular remodeling after stroke.