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Abstract #4498

Stem Cell Treatment of Hemorrhagic Lesions Investigated by Longitudinal DTI Study of a Monkey Model

Chenlu Feng1, Qinyu Zeng1, Zhengguang Chen2, Tie-Qiang Li3, Xiaoming Yin1, Jianwei Huo1, Ming Feng4, Renzhi Wang4

1Department of Radiology, Beijing Coal General Hospital, Beijing, China; 2Department of Radiology, First Hospital of Tsinghua University, Beijing, China; 3Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden; 4Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China

The treatment of hemorrhagic lesion with neuronal stem cell procedure was studied by diffusion tensor imaging in a monkey model using a clinical 3T MRI system. The longitudinal changes of the fractional anisotropy indicate that the procedure at the dosage of 0.5-2.5 million cells is very effective and DTI is a useful tool to monitor the time course of the neuronal repair and fiber track regeneration process.