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Abstract #4499

Cerebral Blood Volume Imaging of Spreading Depression in S218L Mouse Model of Familial Hemiplegic Migraine Type 1

Kwangyeol Baek1,2, Katherina Eikermann_Haerter3, Woo Shim1,2, Cenk Ayata3, Guangping Dai1, Jeong Kon Kim4, Bruce R. Rosen1, Jaeseung Jeong2, Young Ro Kim1

1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2Bio and Brain Engineering, KAIST, Daejeon, Korea, Republic of; 3Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 4Radiology, Asan Medical Center, Seoul, Korea, Republic of

Spreading depression (SD) is a propagating wave of cellular depolarization, and implicated in pathophysiology of migraine and peri-infarct depolarization. In last decade, MRI started to be used for non-invasive imaging of SD, but not much is known about the neurovascular coupling in SD, especially for subcortical regions. We investigated CBV changes induced by SD in cortical and subcortical regions using intravenous contrast agent. We observed marked CBV increase (up to 20%) in cortex, striatum, and hippocampus, but not in thalamus. The CBV response gradually reached peak ~5 min after the neuronal depolarization, suggesting neurovascular coupling is largely modified in SD.