Jessica A. M. Bastiaansen1,2, Xiaowei Zhang1,
Russell E. Jacobs1
1Biological Imaging Center, California
Institute of Technology, Pasadena, CA, United States; 2CIBM, EPFL,
Lausanne, Switzerland
In
MEMRI, quantitative analysis of signal intensity is used to monitor Mn
transport and accumulation, translating signal intensity into concentration.
However, several factors may affect the relaxation behavior of Mn and little
is known about the cellular uptake and distribution as well as whether the
detection limit of Mn changes in different brain regions. Here we investigated
changes in Mn relaxation behavior in cortical and striatal areas of the mouse
brain in vivo and show that relaxation behavior is brain region-specific. The
above has implications on the quantification of axonal transport rates and Mn
concentration.
Keywords