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Abstract #4502

Limits of Mn Detection in Vivo: Spatial Segregation of Relaxation Behavior

Jessica A. M. Bastiaansen1,2, Xiaowei Zhang1, Russell E. Jacobs1

1Biological Imaging Center, California Institute of Technology, Pasadena, CA, United States; 2CIBM, EPFL, Lausanne, Switzerland

In MEMRI, quantitative analysis of signal intensity is used to monitor Mn transport and accumulation, translating signal intensity into concentration. However, several factors may affect the relaxation behavior of Mn and little is known about the cellular uptake and distribution as well as whether the detection limit of Mn changes in different brain regions. Here we investigated changes in Mn relaxation behavior in cortical and striatal areas of the mouse brain in vivo and show that relaxation behavior is brain region-specific. The above has implications on the quantification of axonal transport rates and Mn concentration.