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Abstract #4501

7 T 87Rb MRI to Assess K+ Dynamics in Ischemic Rat Brain in Vivo

Victor E. Yushmanov1, Alexander Kharlamov1, Tamer S. Ibrahim2,3, Tiejun Zhao4, Fernando E. Boada2,3, Stephen C. Jones, 3,5

1Department of Anesthesiology, Allegheny-Singer Research Institute, Pittsburgh, PA, United States; 2Department of Bioengineering; 3Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 4Siemens Medical Solutions USA, Pittsburgh, PA, United States; 5Departments of Anesthesiology and Neurology, Allegheny-Singer Research Institute, Pittsburgh, PA, United States

To monitor K+ in the brain in vivo, 87Rb MRI in a rat model of focal ischemic stroke was performed. Rats pre-loaded with dietary Rb+ were subjected to MCAO, and 87Rb MRI was implemented using a dedicated built in-house RF coil and a spiral ultrashort-TE sequence (TR/TE of 3/0.07 ms). The data represent the worlds first successful 87Rb MRI in vivo co-registered with an anatomic image, and demonstrate the potential of 87Rb MRI at high fields (7 T) to quantitatively assess the dynamics of K+ efflux from the ischemic brain with 13-min temporal resolution in a single animal.