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Abstract #4506

Manganese-Enhanced MRI of Perilesion Cortex in Subchronic Focal Brain Ischemia

Kevin C. Chan1,2, Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

In this study, MEMRI was employed to investigate into the late changes in Mn2+ enhancement in subchronic focal brain ischemia, with emphases on the temporal evolutions in different subregions of the perilesion cortex. The results of this study may provide a new tool for in vivo longitudinal monitoring of the of salvageable tissues and hence represent potential new therapeutic targets for improving the functional consequences after stroke.