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Abstract #4505

Manganese-Enhanced MRI Detection of Neural Compensatory Changes After Neonatal Monocular Enucleation

Iris Y. Zhou1,2, April M. Chow1,2, Shu Juan Fan1,2, Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

In this study, in vivo MEMRI was introduced to investigate cellular alteration and manganese-induced signal intensity changes after neonatal monocular enucleation. With MEMRI, impaired superior colliculi with high spatial resolution revealing the laminar structure and enhancement of monocular area of primary visual cortex can be observed after neonatal monocular enucleation noninvasively. Such MEMRI approach may be useful in investigation of neural plasticity and the adaptive and compensatory modifications within the brain following neonatal monocular enucleation.