Iris Y. Zhou1,2, April M. Chow1,2,
Shu Juan Fan1,2, Ed X. Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR,
China; 2Department of Electrical and Electronic Engineering, The
University of Hong Kong, Pokfulam, Hong Kong SAR, China
In
this study, in vivo MEMRI was
introduced to investigate cellular alteration and manganese-induced signal
intensity changes after neonatal monocular enucleation. With MEMRI, impaired
superior colliculi with high spatial resolution revealing the laminar
structure and enhancement of monocular area of primary visual cortex can be
observed after neonatal monocular enucleation noninvasively. Such MEMRI
approach may be useful in investigation of neural plasticity and the adaptive
and compensatory modifications within the brain following neonatal monocular
enucleation.
Keywords