Abstract #4509

Detection of Brain Activity During Chronic Pain Using Activity-Induced Manganese-Enhanced MRI in the Ra

Yuko Kawai¹, Masahiro Umeda¹, Yasuharu Watanabe¹, Toshihiro Higuchi², Shoji Naruse³, Chuzo Tanaka²

¹Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan; ²Neurosurgery, Meiji University of Integrative Medicine, Kyoto, Japan; ³Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

IntroductionzNerve injury occasionally induces neuropathic pain, which is a type of chronic pain. The cardinal symptom of neuropathic pain is spontaneous or touch-evoked pain. The purpose of this study is to detect brain activation during foot stimulation by using Activity-induced manganese-enhanced (AIM) MRI in a segmental spinal nerve ligation (SNL) model. Methods The right L5L6 spinal nerves were ligated with 50 silk sutures. AIM MRI were acquired using a 4.7-T MRI system. ResultsPain-induced brain activation was successfully visualized using AIM MRI. It suggested that the AIM MRI is useful for the depiction of the conducting pathway of pain.