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Abstract #4511

Contrasting Roles for CD4 and CD8 T Cells in a Murine Model of T1 Black Hole Formation

Istvan Pirko1, Jeremiah McDole2, Yi Chen2, Scott R. Dunn3, Diana M. Lindquist3, Aaron J. Johnson2

1Department of Neurology, Mayo Clinic, Rochester, MN, United States; 2Department of Neurology, University of Cincinnati, Cincinnati, OH, United States; 3Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

TMEV infection of mice is an accepted model of multiple sclerosis. In C57B6/J mice, the formation of T1 black holes (T1BH) is detectable in this model. In this study we confirmed that CD8 T cells are the main contributors to T1BH formation, whereas CD 4 T cells prevent T1BH formation. We also determined that the involved CD8 T cells are classic epitope specific cytotoxic T cells. T1BH formation is thought to represent neuronal/axonal damage in MS; therefore, it is plausible that CD8 T cells play an important effector role targeted at neurons and axons in MS-related neuroinflammatory diseases.