Istvan Pirko1, Jeremiah McDole2, Yi Chen2, Scott R. Dunn3, Diana M. Lindquist3, Aaron J. Johnson2
1Department of Neurology, Mayo Clinic, Rochester, MN, United States; 2Department of Neurology, University of Cincinnati, Cincinnati, OH, United States; 3Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
TMEV infection of mice is an accepted model of multiple sclerosis. In C57B6/J mice, the formation of T1 black holes (T1BH) is detectable in this model. In this study we confirmed that CD8 T cells are the main contributors to T1BH formation, whereas CD 4 T cells prevent T1BH formation. We also determined that the involved CD8 T cells are classic epitope specific cytotoxic T cells. T1BH formation is thought to represent neuronal/axonal damage in MS; therefore, it is plausible that CD8 T cells play an important effector role targeted at neurons and axons in MS-related neuroinflammatory diseases.