Abstract #4516

Multicomponent Relaxometry (McDESPOT) in the Shaking Pup Model of Dysmyelination

Samuel Anthony Hurley¹, Pouria Mossahebi², Alexey A. Samsonov³, Andrew L. Alexander^1,4, Sean C.L. Deoni⁵, Ron Fisher⁶, Ian D. Duncan⁷, Aaron S. Field,²³

¹Medical Physics, University of Wisconsin, Madison, WI, United States; ²Biomedical Engineering, University of Wisconsin, Madison, WI, United States; ³Radiology, University of Wisconsin, Madison, WI, United States; ⁴Psychiatry, University of Wisconsin, Madison, WI, United States; ⁵Engineering, Brown University, Providence, RI, United States; ⁶Waisman Lab for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States; ⁷Medical Sciences, University of Wisconsin, Madison, WI, United States

mcDESPOT is a recently proposed technique which provides two-component relaxometry using steady-state imaging. The relative fraction of water in two microstructural compartments may be estimated via the myelin water fraction map. We report initial results of this technique on the shaking pup myelin mutant. The shaking pup is a canine model which suffers from dysmyelination without the confounding effects of inflammation or edema, and is thus an excellent model for investigating the sensitivity and specificity of mcDESPOT parameters to myelin content in the brain.