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Abstract #4517

Myelin Visualization Using Q-Space MRI

Keigo Hikishima1,2, Kanehiro Fujiyoshi3, Masayuki Yamada1,4, Yuji Komaki1,2, Suketaka Momoshima5, Kazuo Yagi6, Norikazu Tamaoki1, Yoshiaki Toyama3, Masaya Nakamura3, Hideyuki Okano2

1Central Institute for Experimental Animals, Kasawaki, Kanagawa, Japan; 2Department of Physiology, Keio University; 3Department of Orthopaedic Surgery, Keio University; 4School of Health Science, Fujita Health University; 5Department of Radiology, Keio University; 6Graduate School of Health Science, Tokyo Metropolitan University

One of the most recently developed DWI methodologies is q-space imaging (QSI) which has been used to detect the size of microstructure using higher b-values. We developed the myelin mapping protocol using QSI by focusing on the strong restriction of water diffusion in myelin architecture. We compared myelin mapping with histological findings in spinal cords using dysmyelination mutant mice and monkeys with spinal cord injury. In this study we demonstrated that myelin mapping depicts the presence of myelin in spinal cord.