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Abstract #4519

Metabolite Abnormalities in Rhesus Monkeys During Withdrawal of Methamphetamine: A 1H MR Spectroscopy Study at 3T

Shaolin Yang1, Svetlana Chefer1, D. Bruce Vaupel1, Xi Chen1, Pradeep K. Kurup1, Thomas J. Ross1, Elliot A. Stein1, Yihong Yang1

1National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States

A proton magnetic resonance spectroscopy (1H-MRS) study was performed to examine the metabolite abnormalities in the Rhesus monkeys during the abstinence from a long history of methamphetamine (METH) self-administration. The 1H-MRS spectral data were acquired from the frontal lobe and striatum of Rhesus monkeys at 3T in 5 separate sessions (1-day, 1-week, 1-month, 3-month, and 6-month abstinence, respectively). Compared to the control group (n=5), the total choline (tCho) level in the striatum is significantly elevated during the early abstinence (up to 1 month) and continued to be elevated after 3 months of drug withdrawal in the METH-abstinence group (n=10).