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Abstract #4520

Brain Metabolites B1-Corrected Proton T1 Mapping in the Rhesus Macaque at 3T

Songtao Liu1, Roman Fleysher2, Lazar Fleysher2, Chan-Gyu Joo3, Eva-Maria Ratai3, R Gilberto Gonzalez3, Oded Gonen2

1National Institutes of Health Clinical Center, Bethesda, MD, United States; 2New York University Medical Center, New York, NY, United States; 3Massachusetts General Hospital, Boston, MA, United States

The rhesus macaque brain is an advanced model system for the study of neurological diseases. To correct for unknown T1 weighting in MRS quantification, the B1 corrected T1s of NAA, Cho and Cr in gray and white matter structures of rhesus macaques were measured at 3T. Data was acquired with 3D multivoxel proton MRSI at 180uL resolution. The macaques NAA, Cr and Cho T1s are, 1232, 1238 and 1107ms. These values are in agreement with human 3T in vivo results.