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Abstract #4521

High Spatiotemporal Resolution for Molecular Imaging with BIRDS

Daniel Coman1,2, Robin A. de Graaf3, Douglas L. Rothman, 23, Fahmeed Hyder, 23

1Diagnostic Radiology, Yale University, New Haven, CT, United States; 2Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States; 3Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States

Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) is used for pH/temperature mapping in rat brain. The BIRDS method relies on strong dependence of non-exchangeable protons from thulium based macrocyclics, e.g., TmDOTP5- and TmDOTMA-, for temperature and pH. Although high speed 2D CSI allows ~10μL voxels in rats cerebral cortex within 5 minutes, many applications require whole brain coverage and high spatiotemporal resolution. Here we demonstrate a 3D CSI of a cm field-of-view with 1μL voxels in 5 minutes using reduced k-space spherical encoding, which represents an order of magnitude sensitivity enhancement from the 2D CSI data acquisition.